What is the Cycloastragenol?

Cycloastragenol is Colorless needle crystal, while it's Molecular Formula is C30H50O5. Colorless needle crystal Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.

What is the CAS number for Cycloastragenol?

The CAS number of Cycloastragenol is 84605-18-5.

What is Cycloastragenol (84605-18-5) used for?

Cycloastragenol (TA-65), a small-triterpenoid purified from the root of an Asian medicinal herb, has currently received particular attention for its potential to regulate transcription of telomerase. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.InChI:InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22?,23?,26+,27-,28-,29?,30?/m0/s1

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84605-18-5

Product Name:Cycloastragenol
Molecular Formula:C₃₀H₅₀O₅
Molecular Weight:490.724
Appearance:Colorless needle crystal

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Product Details

Appearance:Colorless needle crystal

Purity:99%

Factory Supply Hot Sale 84605-18-5 Cycloastragenol with Safe Transportation

Molecular Formula:C30H50O5
Molecular Weight:490.724
Appearance/Colour:Colorless needle crystal
Vapor Pressure:8.17E-18mmHg at 25°C
Refractive Index:1.582
Boiling Point:617.2 °C at 760 mmHg
PKA:14.57±0.29(Predicted)
Flash Point:327.1 °C
PSA：90.15000
Density:1.2 g/cm³
LogP:4.43660

Cycloastragenol(Cas 84605-18-5) Usage

Description	Cycloastragenol is a triterpenoid isolated from various legume species in the genus Astragalus that is purported to have telomerase activation activity. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.
Uses	Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.
Definition	ChEBI: A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.

InChI:InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22?,23?,26+,27-,28-,29?,30?/m0/s1

84605-18-5 Relevant articles

Structure of cyclochivinoside C from Astragalus chivensis

Naubeev,Uteniyazov

, p. 560 - 562 (2007)

The new cycloartane glycoside cyclochivi...

Cycloascauloside a from Astragalus caucasicus leaves

Alaniya,Chkadua,Gigoshvili,Kemertelidze

, p. 445 - 448 (2006)

The new cycloartane glycoside cycloascau...

The use of two-phase acid hydrolysis method of preparing ring [...] (by machine translation)

-

Paragraph 0024-0066, (2019/07/08)

The invention belongs to the field of ph...

Compositions and methods for skin conditioning

-

Page/Page column 21, (2016/02/26)

Methods and cosmetic compositions for co...

Triterpene glycosides from astragalus. Structure of cyclolehmanoside C from A. lehmannianus

Zhanibekov,Naubeev,Uteniyazov,Bobakulov, Kh. M.,Abdullaev

, p. 475 - 477 (2013/09/02)

The structure of a new cycloartane trite...

Flavonoid and cycloartane glycosides from seeds of Koelreuteria paniculata

Sutiashvili,Alaniya,Mshvildadze,Skhirtladze,Pichette,Lavoie

, p. 395 - 397 (2013/07/26)

84605-18-5 Process route

: 84883-00-1
20S,24R-epoxycycloartan-3,6,16,25-tetraol-3-O-β-D-(2'-O-acetyl)xylopyranosyl-6-O-β-D-xylopyranoside

: 58-86-6
D-xylose

: 84605-18-5
20(S),24(R)-epoxy-9β,19-cyclolanostan-3β,6α,16β,25-tetrol

Conditions

Conditions	Yield
Acidic conditions;

: 83207-58-3,84687-43-4
astragaloside IV

: 84605-18-5,90865-25-1,104112-00-7,78574-94-4
cycloastragenol

Conditions

Conditions	Yield
With hydrogenchloride; In methanol; at 20 ℃; for 168h;	64%
With hydrogenchloride; In methanol; at 20 ℃; for 168h;	64%
With hydrogenchloride; In ethanol; benzene; for 24h; Heating;	30 mg
With sulfuric acid; In methanol; for 3h;	30 mg
Multi-step reaction with 2 steps 1: 47 mg / H₂SO₄ / methanol / 4 h / Heating 2: 17 mg / H₂SO₄ / methanol / 4 h / Heating With sulfuric acid; In methanol;
Multi-step reaction with 2 steps 1: 58 mg / H₂SO₄ / methanol / 4 h / Heating 2: 11 mg / H₂SO₄ / methanol; H₂O / 4 h / Heating With sulfuric acid; In methanol; water;
With water; Acidic conditions;
astragaloside IV; With sodium periodate; In methanol; water; at 20 ℃; With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h; With sulfuric acid; In methanol; water; for 24h; pH=2;	384 mg
With hydrogenchloride; In methanol; chloroform; water; at 20 ℃; for 144h; Concentration;

84605-18-5 Upstream products

88192-85-2
Cycloaraloside A
135101-62-1
cyclocarposide
134563-28-3
cycloaraloside E
142735-27-1
Cycloaraloside F

84605-18-5 Downstream products

86541-79-9
astragenol
1255151-99-5
C₃₇H₅₄O₆
1255152-16-9
C₄₄H₆₇NO₈
1255151-95-1
C₄₄H₆₇NO₈

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